The European Medicines Agency (EMA) will review an application for linerixibat, an experimental oral therapy for intense itching associated with primary biliary cholangitis (PBC).
News
CHOLESTASIS
NewsResearchers develop mutation database, mouse model for PFIC2
Researchers have developed a database of all ABCB11 mutations known to cause progressive familial intrahepatic cholestasis type 2 (PFIC2) and a new mouse model…
FATTY LIVER DISEASE
NewsEMA committee supports Rezdiffra’s OK for fatty liver disease MASH
A committee of the European Medicines Agency (EMA) has granted a positive opinion to Rezdiffra (resmetirom) to treat some people with metabolic dysfunction-associated steatohepatitis (MASH),…
ALAGILLE SYNDROME
NewsTargeted chemotherapy effective for HCC in woman with Alagille
A targeted treatment called transarterial chemoembolization (TACE) successfully helped control hepatocellular carcinoma (HCC), the most common type of liver cancer, in a young woman with…
CHOLANGITIS
NewsMononucleosis linked to higher risk of developing PSC: Study
Note: This story was updated Aug. 8, 2025, to correct that infectious mononucleosis was linked to a 4.6 times higher risk of future PSC, not  a…
CHOLESTASIS
NewsNew MYO5B gene mutation detected in man with PFIC type 10
A combination of two mutations in the MYO5B gene, including one that has not been previously reported, was the likely cause of a mild form…
FATTY LIVER DISEASE
NewsDiabetes drug dapagliflozin shows benefits for MASH in Phase 3 trial
Daily treatment with the diabetes medication dapagliflozin eased disease severity for people with metabolic dysfunction-associated steatohepatitis (MASH), a severe form of fatty liver disease,…
BILIARY ATRESIA
NewsCombined blood measure may detect biliary atresia in newborns
Combining the levels of two liver damage markers, obtained from standard blood tests, can accurately discriminate infants with biliary atresia from those without the…
HEPATITIS
NewsClinical testing begins for vaccine to treat hepatitis B
Astrivax Therapeutics has begun clinical testing of AVX70371, an experimental vaccine designed to treat hepatitis B. “Starting clinical development with AVX70371 is the first…
CHOLANGITIS
NewsTrial of golexanolone for PBC cognitive symptoms to resume
A Phase 1b/2a clinical trial of golexanolone, Umecrine Cognition’s candidate therapy for cognitive symptoms and fatigue related to primary biliary cholangitis (PBC), will resume…
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