February is Rare Liver Diseases Month, and this year, the Global Liver Institute (GLI) is highlighting the importance of early diagnosis for better health…
Cholestasis
An international group of patients, clinicians, and researchers has recommended a standardized set of clinical measurements to assess outcomes in intrahepatic cholestasis of pregnancy…
CHOLESTASIS
NewsEarly trial results testing maralixibat for hard-to-treat itching due by year’s end
A global clinical trial testing Mirum Pharmaceuticals‘ maralixibat for treatment-resistant itching, or pruritus, associated with rare cholestatic conditions is expected to complete patient…
Low vitamin D levels in the first trimester of pregnancy are significantly associated with an increased risk of developing intrahepatic cholestasis of pregnancy (ICP),…
CHOLESTASIS
NewsPlant compounds offer new clues about gut bacteria and cholestasis
Two plant-based compounds — ferulic acid and wogonin — may help protect the liver in cholestasis by influencing the growth of certain gut bacteria,…
Women who develop severe intrahepatic cholestasis of pregnancy (ICP) at a later time in pregnancy have a higher risk of stillbirth, a study shows.
CHOLESTASIS
NewsHeart complications common in children with PFIC, study finds
About half of children with progressive familial intrahepatic cholestasis (PFIC) were found to have cirrhotic cardiomyopathy (CCM), a form of heart disease, in a…
CHOLESTASIS
NewsCommon virus may play a role in ICP development, study finds
Infection with human cytomegalovirus (HCMV), a common and usually harmless virus, may play a role in the development of intrahepatic cholestasis of pregnancy (ICP),…
CHOLESTASIS
NewsTwo new USP53 gene mutations cause mild PFIC in Russian boy
Two new mutations in the USP53 gene were identified as the cause of a milder form of progressive familial intrahepatic cholestasis (PFIC), which resembled…
CHOLESTASIS
NewsNew biomarkers may help detect pregnancy-linked liver complication
Levels of the metabolite palmitic acid and the protein ACSL1 in the bloodstream can accurately detect the presence and severity of intrahepatic cholestasis of…
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