Cholestasis

April is officially recognized in the U.S. as National Donate Life Month, an opportunity to highlight the extraordinary impact of organ donation, and the…

Blood levels of certain pro-inflammatory proteins are elevated in people with intrahepatic cholestasis of pregnancy (ICP), and these inflammatory markers may help predict the…

Testing for bilirubin, a liver damage marker, in urine is not reliable for screening or diagnosing cholestasis (slowed flow of the digestive fluid bile)…

Researchers in China have developed and validated a new prediction model that can help distinguish pregnant women with intrahepatic cholestasis of pregnancy (ICP) who…

A global clinical trial testing Mirum Pharmaceuticals’ oral therapy maralixibat in people with itching, or pruritus, due to rare cholestatic conditions has finished…

Long-term exposure to particles produced from cooking grilled meat can trigger liver damage and cholestasis — slowing or stalling of the digestive fluid bile…

Among children and adolescents with progressive familial intrahepatic cholestasis (PFIC), severe itch significantly affects sleep, overall perceptions of health, and the family’s quality of…

Progressive familial intrahepatic cholestasis type 3 (PFIC3) can cause abnormalities in copper metabolism that mimic another condition, Wilson’s disease, and early distinction is key…

Volixibat, Mirum Pharmaceuticals’ experimental oral treatment, may help reduce circulating bile acids and ease itch in pregnant women with intrahepatic cholestasis of pregnancy…

Health Canada has approved Mirum Pharmaceuticals’ oral therapy Livmarli (maralixibat) for cholestatic pruritus — that is, itching due to impaired bile flow —…