Cholestasis

Scientists in the U.K. have created a liver-specific gene therapy that could potentially treat arthrogryposis renal dysfunction cholestasis (ARC) syndrome, a fatal childhood disease marked…

A liver transplant with an uncle serving as a living donor successfully managed advanced progressive familial intrahepatic cholestasis type 2 (PFIC2) in a one-year-old…

Children with progressive familial intrahepatic cholestasis (PFIC) who carry mutations that completely eliminate a protein’s production are nearly three times more likely to require…

A newly developed compound called HEP-50768 — identified through large-scale screening and chemically optimized to be more effective — was shown to significantly reduce itch…

Researchers have identified 27 genetic variants linked to intrahepatic cholestasis of pregnancy (ICP), including those located in 10 newly discovered DNA regions, uncovering key…

Blood levels of xenin-25, a small protein (peptide) produced in the gut, may serve as a biomarker to help diagnose intrahepatic cholestasis of pregnancy,…

People with progressive familial intrahepatic cholestasis (PFIC), along with their families and clinicians, collaborated on a two-year project to develop a knowledge base for…

A new prediction tool may help assess the risk of preterm birth (before 37 weeks of gestation) in women affected by intrahepatic cholestasis of…

Rare genetic liver conditions like progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome pose a substantial financial and quality-of-life burden on families, a study…

In a rat model of segmental cholestasis, a condition in which bile flow is blocked in certain areas of the liver, treatment with pioglitazone…