Imdusiran combos lead to functional cure in some cases of hepatitis B
The investigational treatment imdusiran used as part of combination therapy regimens has led to a functional cure for eight people with chronic hepatitis…
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Linerixibat reduces itch, improves sleep in PBC Phase 3 trial
Nearly six months of treatment with the experimental oral candidate linerixibat significantly reduced itch and itch-related sleep problems for adults with primary biliary cholangitis…
Cilnidipine, bexarotene ease liver damage in rat model of cholestasis
Preventive treatment with cilnidipine and bexarotene significantly reduced markers of inflammation, liver damage, and oxidative stress, a type of cellular damage, in a rat model…
MASLD in pregnancy tied to higher risk of premature birth: Study
Women with metabolic dysfunction-associated steatotic liver disease (MASLD), a form of fatty liver disease, are more likely to give birth prematurely, but their babies…
Time between biliary atresia diagnostic tests, Kasai surgery varies
Despite the established link between a younger age at standard Kasai surgery and better outcomes for infants with biliary atresia, the time between the…
AHB-137 effective for chronic hepatitis B: Phase 2b clinical trial
AHB-137, Ausperbio’s experimental therapy, safely and effectively suppressed the disease-causing hepatitis B virus (HBV) in people with chronic hepatitis B, according to interim…
Even with past treatment, Livdelzi works on primary biliary cholangitis
The efficacy of Livdelzi (seladelpar) at treating primary biliary cholangitis (PBC) is similar irrespective of whether patients previously received other medications, according to…
RTY-694 shows promise in models of liver, bile duct diseases PFIC, PSC
An experimental oral therapy by Rectify Pharmaceuticals called RTY-694 reduced markers of slowed bile flow and inflammation in a mouse model of progressive…
Children with fatty liver disease MASLD have higher mortality risk
Children with metabolic dysfunction-associated steatotic liver disease (MASLD), a form of fatty liver disease, are more than 40 times more likely to die than…
New JAG1 mutation seen as likely cause of Alagille case
Researchers have identified a new mutation in the JAG1 gene as the likely cause of Alagille syndrome in an 18-year-old man who also had persistent…
