Phase 1 trial of gene-editing therapy for hepatitis B cleared in US
Precision Biosciences has been given the go-ahead to expand a Phase 1 clinical trial testing PBGENE-HBV, its gene-editing therapy for chronic hepatitis…
Marisa Wexler, MS, Senior Science Writer—
Articles by Marisa Wexler
New ABCB4 mutation found to be cause of PFIC3 in young woman
A new mutation in the ABCB4 gene was found to cause progressive familial intrahepatic cholestasis (PFIC) type 3 in a young woman, a case…
Cytokine levels may predict Kasai procedure outcome in biliary atresia
Blood levels of certain immune signaling molecules called cytokines may help to predict the likelihood of a successful outcome with the…
Bemnifosbuvir-ruzasvir Phase 3 trials in hepatitis C launch in April
Atea Pharmaceuticals plans to launch two parallel Phase 3 trials soon to test its investigational combination therapy of bemnifosbuvir and ruzasvir for people with…
Rezdiffra reduces scarring in MASH with compensated cirrhosis: Trial
Long-term treatment with Rezdiffra (resmetirom) reduces liver scarring for most people with compensated cirrhosis, or irreversible scarring in a still-functioning liver, due to metabolic…
Patient identification guidelines may help diagnose biliary atresia earlier
A team of experts in the U.S. and Canada have developed patient identification guidelines to help pediatric primary care providers, or PCPs, in making an…
Phase 2 trial of DD01 in treating MASH completes enrollment
D&D Pharmatech has finished enrolling a Phase 2 clinical trial of its experimental therapy DD01 in overweight or obese adults with metabolic dysfunction-associated steatohepatitis…
Antibiotic may ease IBD related to primary sclerosing cholangitis
Four weeks of treatment with vancomycin, a common antibiotic, lowered inflammatory bowel disease (IBD) in people with primary sclerosing cholangitis (PSC), data from a…
Traffic pollution may increase risk of fatty liver disease: Mouse study
Long-term exposure to air pollution from traffic, even at relatively low concentrations, may increase the risk of fatty liver disease, according to a new…
Biliary atresia blood markers augur post-Kasai liver transplant need
Children with biliary atresia who have higher blood levels of the matrix metalloproteinase 7 (MMP-7) and alkaline phosphatase (ALP) enzymes at the time of…
