AI models may aid intrahepatic cholestasis of pregnancy prediction
New artificial intelligence (AI) models based on 11 possible risk factors of intrahepatic cholestasis of pregnancy (ICP) can accurately distinguish between healthy pregnant women,…
Cholestasis
Livmarli, Bylvay safely reduce pruritus in PFIC, Alagille children
Livmarli (maralixibat) and Bylvay (odevixibat) can help relieve itching, or pruritus, and reduce liver damage in children with progressive familial intrahepatic cholestasis (PFIC) or…
Genetic variant that raises ICP risk is protective against hepatitis B
A genetic variant unique to East Asians increases the risk of intrahepatic cholestasis of pregnancy (ICP) by more than 16 times, but it likely…
How I navigated my 2nd pregnancy as a carrier of PFIC type 3
This week I had an appointment with a new doctor to check on my health following my experience with intrahepatic cholestasis of pregnancy (ICP), a…
Bylvay, Kayfanda in EU, safely treats PFIC: Real-world study
In real-world use, Kayfanda (odevixibat) — available under the brand name Bylvay in the U.S. — lowered blood bile acid levels and eased…
Maralixibat Phase 3 trial for cholestasis-related itch is enrolling
Enrollment is ongoing in a Phase 3 clinical trial that’s designed to evaluate Mirum Pharmaceuticals’ maralixibat for treatment-resistant itching, or pruritus, associated with rare…
New TJP2 mutations detected in girl with mild PFIC4
A combination of two new mutations in the TJP2 gene was identified as the cause of a mild form of progressive familial intrahepatic cholestasis type 4 (PFIC4) in…
Our daughter’s PFIC diagnosis made us rethink drinking at Christmas
I love Christmas. What’s not to like about being with friends and family, taking winter walks, and eating too much food? My dad’s always been…
Diet rich in omega-3 fatty acids may lower risk of ICP, scientists say
Higher blood levels of omega-3 fatty acids, fatty molecules found in food and shown to have health benefits, significantly associate with a lower risk of…
Cholestasis common in COVID 19-linked ARDS, study shows
Cholestasis is a common complication among critically ill people with COVID 19-associated acute respiratory distress syndrome (ARDS), a life-threatening form of respiratory failure, a…
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