Among children and adolescents with progressive familial intrahepatic cholestasis (PFIC), severe itch significantly affects sleep, overall perceptions of health, and the family’s quality of…
Cholestasis
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Cholestasis is a medical term that’s used to describe a slowing or stalling of bile flow out of the liver. Bile is a yellow-greenish fluid produced by the liver that helps to break down certain fatty molecules and proteins into smaller pieces during digestion. It also carries certain waste products from the liver into the intestines to be excreted in feces.
Cholestasis treatment options aim to restore the normal flow of the digestive fluid bile through the bile ducts, a series of tubes that carry the sticky yellow-greenish fluid out of the liver where it's made and to the small intestine.
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Progressive familial intrahepatic cholestasis type 3 (PFIC3) can cause abnormalities in copper metabolism that mimic another condition, Wilson’s disease, and early distinction is key…
Volixibat, Mirum Pharmaceuticals’ experimental oral treatment, may help reduce circulating bile acids and ease itch in pregnant women with intrahepatic cholestasis of pregnancy…
