Gene therapy shows promise for Alagille liver disease: Mouse study
The use of an experimental, one-time gene therapy in a mouse model of Alagille syndrome increased the number of bile ducts — tubes that…
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AusperBio raises $50M to advance AHB-137 for chronic hepatitis B
AusperBio raised $50 million to advance the development of chronic hepatitis B treatment AHB-137. The company said the funding will help it launch Phase…
FDA to review linerixibat for PBC-related itching
The U.S. Food and Drug Administration (FDA) has accepted for review GSK’s application seeking the approval of its oral treatment linerixibat for intense itching, or…
New mutation likely cause of PFIC type 1 in siblings with liver failure
A novel mutation in the ATP8B1 gene was the likely cause of progressive familial intrahepatic cholestasis (PFIC) type 1 in two siblings in India…
Fatty liver disease MASLD to affect 16% of teens, young adults by 2050
The total number of adolescents and young adults with metabolic dysfunction-associated steatotic liver disease (MASLD), a form of fatty liver disease, has been steadily…
Early Kasai surgery linked to better outcomes, lower care costs in US
The cumulative healthcare costs for infants with biliary atresia can increase substantially if they undergo their initial treatment, the Kasai surgery, after 2 months…
Sobriety restrictions on hepatitis C treatment raise healthcare costs
People with hepatitis C in the U.S. who are insured through state Medicaid programs that require them to be sober to access treatment are…
30% rise due in primary sclerosing cholangitis prevalence by 2040
The global prevalence of primary sclerosing cholangitis (PSC), or the total number of existing cases, is expected to increase substantially over the next several…
ACER3 enzyme may be therapeutic target in cholestasis: Lab study
ACER3, an enzyme involved in the metabolism of fat-like signaling molecules known as ceramides, plays a detrimental role in cholestasis-related liver damage — and,…
Elevated skull pressure leads to vision loss in Alagille: Case study
A young woman with Alagille syndrome (AGLS) developed profound vision loss due to increased pressure inside the skull following multiple brain bleeds, according to…
