Low blood levels of vitamin B6 — found in certain foods and essential for metabolism and immune function in the body — can increase the…
News
Rare genetic liver conditions like progressive familial intrahepatic cholestasis (PFIC) and Alagille syndrome pose a substantial financial and quality-of-life burden on families, a study…
FATTY LIVER DISEASE
NewsMadrigal Pharmaceuticals expands MASH pipeline with genetic treatment
Madrigal Pharmaceuticals has secured worldwide rights to develop ARO-PNPLA3, an experimental treatment created by Arrowhead Pharmaceuticals for people with metabolic dysfunction-associated steatohepatitis (MASH),…
BILIARY ATRESIA
NewsCMV marker in bile duct cells tied to worse biliary atresia outcomes
Children with biliary atresia who had evidence of active cytomegalovirus (CMV) infection involving bile duct cells in the liver had signs of more severe…
HEPATITIS
NewsAdvocates push for testing during Hepatitis Awareness Month
May is Hepatitis Awareness Month, and advocates are working to spread the word about viral hepatitis — a group of infections that cause liver…
Twice-daily treatment with volixibat, Mirum Pharmaceuticals’ oral investigational therapy for primary sclerosing cholangitis (PSC) significantly outperformed a placebo in reducing moderate to severe…
In a rat model of segmental cholestasis, a condition in which bile flow is blocked in certain areas of the liver, treatment with pioglitazone…
FATTY LIVER DISEASE
NewsMASH treatment efimosfermin wins new designations in US and EU
A once-monthly investigational therapy for metabolic dysfunction-associated steatohepatitis (MASH), called efimosfermin, has earned two new regulatory designations — one in the U.S. and the other…
ALAGILLE SYNDROME
NewsFor girl in Asia, limited access to genetic testing delayed an Alagille diagnosis
Due to limited access to genetic testing, a young girl with Alagille syndrome in Indonesia was misdiagnosed in infancy with biliary atresia —…
The U.S. Food and Drug Administration (FDA) has accepted and placed under priority review an application seeking approval of bepirovirsen, GlaxoSmithKline (GSK)’s investigational therapy,…
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