New mutation likely cause of PFIC type 1 in siblings with liver failure
A novel mutation in the ATP8B1 gene was the likely cause of progressive familial intrahepatic cholestasis (PFIC) type 1 in two siblings in India…
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Fatty liver disease MASLD to affect 16% of teens, young adults by 2050
The total number of adolescents and young adults with metabolic dysfunction-associated steatotic liver disease (MASLD), a form of fatty liver disease, has been steadily…
Early Kasai surgery linked to better outcomes, lower care costs in US
The cumulative healthcare costs for infants with biliary atresia can increase substantially if they undergo their initial treatment, the Kasai surgery, after 2 months…
Sobriety restrictions on hepatitis C treatment raise healthcare costs
People with hepatitis C in the U.S. who are insured through state Medicaid programs that require them to be sober to access treatment are…
30% rise due in primary sclerosing cholangitis prevalence by 2040
The global prevalence of primary sclerosing cholangitis (PSC), or the total number of existing cases, is expected to increase substantially over the next several…
ACER3 enzyme may be therapeutic target in cholestasis: Lab study
ACER3, an enzyme involved in the metabolism of fat-like signaling molecules known as ceramides, plays a detrimental role in cholestasis-related liver damage — and,…
Elevated skull pressure leads to vision loss in Alagille: Case study
A young woman with Alagille syndrome (AGLS) developed profound vision loss due to increased pressure inside the skull following multiple brain bleeds, according to…
Imdusiran combos lead to functional cure in some cases of hepatitis B
The investigational treatment imdusiran used as part of combination therapy regimens has led to a functional cure for eight people with chronic hepatitis…
Linerixibat reduces itch, improves sleep in PBC Phase 3 trial
Nearly six months of treatment with the experimental oral candidate linerixibat significantly reduced itch and itch-related sleep problems for adults with primary biliary cholangitis…
Cilnidipine, bexarotene ease liver damage in rat model of cholestasis
Preventive treatment with cilnidipine and bexarotene significantly reduced markers of inflammation, liver damage, and oxidative stress, a type of cellular damage, in a rat model…
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