Linerixibat offers PBC patients fast relief from intense itching in trial
The experimental oral therapy linerixibat from GlaxoSmithKline (GSK) offers rapid and sustained relief from severe itch in adults with primary biliary cholangitis (PBC),…
Margarida Maia, PhD, Science Writer—
Articles by Margarida Maia
Two new USP53 gene mutations cause mild PFIC in Russian boy
Two new mutations in the USP53 gene were identified as the cause of a milder form of progressive familial intrahepatic cholestasis (PFIC), which resembled…
Gene-editing therapy PBGENE-HBV shows encouraging trial results
PBGENE-HBV, Precision BioSciences’ experimental gene-editing therapy for chronic hepatitis B, showed antiviral activity across three doses, with the highest dose approaching the benchmark…
2 simple nutrients may be effective new screening tool for ICP
A new study has identified two dietary nutrients, choline and dimethylglycine, as effective potential biomarkers for diagnosing and monitoring intrahepatic cholestasis of pregnancy (ICP).
Aramchol shows promise as PSC treatment, mouse study finds
Aramchol, a small molecule in the Galmed Pharmaceuticals pipeline, prevented and reversed inflammation and scarring (fibrosis) of the bile ducts in mouse models of…
PBC worst for life quality among autoimmune liver diseases: Study
Adults with autoimmune liver disease experience lower quality of life, especially those with primary biliary cholangitis (PBC), who report more fatigue, sleepiness, and pain…
Bylvay now approved in Canada to treat adults, children with Alagille
Bylvay (odevixibat), an oral medication used to treat cholestatic pruritus — severe itching that results from a buildup of bile acids used in digestion —…
Adding Vitamin D boosts PBC treatment in clinical trial
Adding vitamin D to ursodeoxycholic acid (UDCA) treatment is superior to UDCA alone at reducing symptoms, liver damage markers, and liver scarring in previously untreated…
Thousands of babies born each year with hepatitis C infection
About 74,000 babies are born each year with the virus that causes hepatitis C, and more than 23,000 of them may still have the…
Genetic testing helps identify cause of neonatal cholestasis
Genetic testing can help doctors find the cause of neonatal cholestasis more quickly, so children can receive more targeted treatment sooner, according to a…